13 Apr 2022


Chronic Myelogenous Leukemia Case Study

Format: APA

Academic level: University

Paper type: Case Study

Words: 362

Pages: 1

Downloads: 0

Chronic myeloid leukemia refers to a type of cancer that begins in particular blood-forming cells found in the bone marrow. Genetic change occurs in the early version of the myeloid cells; that is the cells that are responsible for the production of the platelets, most white blood cells, and red blood cells. In this paper, the discussion is about the genetics of CML and the significance of the Philadelphia chromosome. Also how the approach goals of treatment and counseling the patient

Genetics of CML and the significance of the Philadelphia chromosome

The functioning and growth of human beings are based on information found in cell’s chromosomes. Chromosomes contained in molecules of DNA, which is the chemical that bears a person’s gene. A cell duplicates a DNA in its chromosome every time a cell plans to split into two new cells; this can cause an error which could have an effect on genes inside the DNA. Cancer might be due to mutation of the DNA, which turns on tumor suppressor ( a gene that causes death of cells at the right time or slows down cell division) or oncogenes (genes that support cell division and growth). Chronic myeloid leukemia occurs when swapping of DNA (chromosomal material) takes place between chromosomal 22 and 9 during the division of the cell. A portion of chromosomal 22 goes to 9 and fraction of chromosomal 9 goes to 22. The process is called translocation that leads to chromosome 22 being shorter than normal. As a result, the abnormal chromosome is referred to as Philadelphia chromosome. All patients with CML have Philadelphia chromosome that originates in the leukemia cells. DNA between chromosome swaps to form a new gene known as BCR-ABL, this protein cause CML cells to develop and replicate out of control. Few CML patients have BCR-ABL except Philadelphia chromosome. (Talpaz et al, 2006)

It’s time to jumpstart your paper!

Delegate your assignment to our experts and they will do the rest.

Get custom essay

Goals of Treatment and Counseling of CML Patient.

Goals of Chronic Myelogenous Leukemia treatment include cytogenetic remission (normal chromosome come back with Ph+ cells), molecular remission (PCR result for mutational BCR/ABL) and hematologic remission (physical examination and standard complete blood cell count). CML patients are encouraged to undergo full health assessment including laboratory tests, emotional and physical status, diagnosis and to accesses caregivers in communities, homes and resource centers. The CML patient is taught how to manage their condition to live longer. (Kurzrock et al, 2003)


Talpaz M, Shah NP, Kantarjian H, et al. (June 2006).  "Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias" N. Engl. J. Med.  354 (24): 2531–41.  

 Kurzrock,R,;Kantarjian, H. M.; Druker, B. J.;Talpaz, M. (2003). "Philadelphia chromosome-positive leukemia: From basic mechanisms to molecular therapeutics". Annals of Internal Medicine 138 (10): 819–830.   

Cite this page

Select style:


StudyBounty. (2023, September 17). Chronic Myelogenous Leukemia Case Study.


Related essays

We post free essay examples for college on a regular basis. Stay in the know!

Vaccine Choice Canada Interest Group

Vaccine Choice Canada Interest Group Brief description of the group Vaccine Choice Canada, VCC, denotes Canada's leading anti-vaccination group. Initially, the anti-vaccination group was regarded as Vaccination...

Words: 588

Pages: 2

Views: 146

Regulation for Nursing Practice Staff Development Meeting

Describe the differences between a board of nursing and a professional nurse association. A board of nursing (BON) refers to a professional organization tasked with the responsibility of representing nurses in...

Words: 809

Pages: 3

Views: 191

Moral and Ethical Decision Making

Moral and Ethical Decision Making Healthcare is one of the institutions where technology had taken lead. With the emerging different kinds of diseases, technology had been put on the frontline to curb some of the...

Words: 576

Pages: 2

Views: 89

COVID-19 and Ethical Dilemmas on Nurses

Nurses are key players in the health care sector of a nation. They provide care and information to patients and occupy leadership positions in the health systems, hospitals, and other related organizations. However,...

Words: 1274

Pages: 5

Views: 77

Health Insurance and Reimbursement

There are as many as 5000 hospitals in the United States equipped to meet the health needs of a diversified population whenever they arise. The majority of the facilities offer medical and surgical care for...

Words: 1239

Pages: 4

Views: 438

Preventing Postoperative Wound Infections

Tesla Inc. is an American based multinational company dealing with clean energy and electric vehicles to transition the world into exploiting sustainable energy. The dream of developing an electric car was...

Words: 522

Pages: 5

Views: 357


Running out of time?

Entrust your assignment to proficient writers and receive TOP-quality paper before the deadline is over.