The research area that I am interested in is autoimmunity, tolerance, and immune-mediated pathology. I am specifically advancing the research in T cells, considering that they are pivotal players in the immune responses. I will be studying these cells since, in as much as they are beneficial in combating the infections and cancer, they can be harmful in autoimmunity and immunopathology states. The research comes into practice considering that the importance of T cells is evidenced by the severed autoimmunity that develops in mice and humans that lack the regulatory T-cells. The study will expound on the active investigation of how the signal transduction process impacts the development, homeostasis, expansion, and the function of the regulatory T cells. The findings in this research will be translated in the form of therapeutic approaches that can be used in preventing inflammatory diseases like multiple sclerosis diabetes, rheumatoid arthritis, and the inflammatory bowel disease.
The research will be essential as it will help in understanding the molecular mechanism of the inflammatory diseases including sclerosis and type 1 diabetes and to give preventive mechanisms. The research is guided by the fact that although the etiology and triggers of these diseases vary, the common pathology outcome of autoimmune diseases is the destruction of the self-tissues through the activation of the lymphoid and myeloid cells by autoimmune inflammation. I will further be examining the development of autoimmune inflammation and the coordinated expression of the myriad genes that encode the antigen receptors.
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The study is vital for the clinical practice as it is guided by my previous researches and studies including the research on the role of Target of Rapamycin (TOR) in the growth of cells. My previous research involved the determination of the recovery phenotypes by exposing yeast strains in rapamycin for specified periods. Requisite to the success of my current research is the adeptness in my scientific techniques and the ability to collaborate with other scientists while carrying out different projects. This implies that I do not only have the passion of exploring the scientific world, but also to help in solving biological problems related to animal and human health. The research in autoimmunity, tolerance, and immune-mediated pathology will, therefore, be part of the developments of continued understanding of the disease prevention methods as my area of interest.
The first Penn researcher I am interested in is Laura F Su, M.D. Ph.D, whose general focus is on human CD4+ T cell immunity. The research will be helpful as it would help in understanding how T-cell cross-reactivity and the risks for developing autoimmunity. I am also interested in the work of Eline Tjetske Luning Prak, MD, Ph.D, whose work concentrates on the study of antibody repertoire in health and diseases. I am also interested in the work of Taku Kambayashi, M.D, Ph.D, whose work focuses on the regulation of T cell responses including the regulatory T cell expansion and homeostasis, natural killer (NK) cell education and signaling.
