Pathophysiology of RA is associated with the abnormal functioning of the body immunity that leads to the destruction of the tissues.
Rheumatoid arthritis result from alteration of the body’s immune system that causes it to attack the body tissues. The immunity starts attacking the organs and tissues as it does to viruses, bacteria, among other foreign bodies in the system.
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Consequently, this autoimmune cause the antibodies acts on the body tissues as harmful substances which may result in inflammation and the damage of these organs (Ganapathy et al 2017). The parts that are prone to attack by this condition are tissues on the joints and may lead to their permanent damage.
Maladaptive responses in rheumatoid arthritis may occur when the body immune systems may produce antibodies that may act upon harmless body tissues while physiological responses in this disorder are the normal functioning of the body to fight pathogens from the system (Straub & Schradin 2016).
Therefore, physiological responses enhance the body to recognize the attack of the body by pathogens and react by developing antigen-specific responses to kill them. Hence, the difference between maladaptive and physiological responses is that the latter is harmful while the former is helpful in the RA disorder.
Rheumatoid arthritis disorder is associated with inflammation of and pain in the body tissues especially the joints. These symptoms are caused by the attack of the healthy tissues in the joints, hence the medication to treat this disorder would intend to prevent the swelling and pain.
Consequently, the Disease-modifying antirheumatic drugs (DMARDs) are recommended to the patients with this condition to decrease inflammation and can eventually cause healing of these tissues (Kumar et al 2016). Examples of DMARDs may include; hydroxychloroquine, minocycline, leflunomide among others.
Biologics are another type of RA drugs that are injected into the patients’ systems to hinder inflammatory cases caused by immune cells.
The most common drugs of this kind may include; abatacept, rituximab, adalimumab and many others. Besides, if the DMARDs and biologics do not work in the systems of a patient, the doctor may recommend Janus associated kinase inhibitors which interfere with the genes as well as the functioning of immune cells.
References
Ganapathy, S., Vedam, V., Rajeev, V., & Arunachalam, R. (2017). Autoimmune Disorders-Immunopathogenesis and Potential Therapies. Journal of Young Pharmacists, 9(1).
Kumar, L. D., Karthik, R., Gayathri, N., & Sivasudha, T. (2016). Advancement in contemporary diagnostic and therapeutic approaches for rheumatoid arthritis. Biomedicine & Pharmacotherapy, 79, 52-61.
Straub, R. H., & Schradin, C. (2016). Chronic inflammatory systemic diseases: An evolutionary trade-off between acutely beneficial but chronically harmful programs. Evolution, medicine, and public health, 2016(1), 37-51.
