Genetic glitches result in mental health illnesses including Schizophrenia, bipolar disorder, and recurrent depressive episodes. Specifically, chromosomal aberrations predispose some genes to schizophrenia based on a linkage strategy (Bassett, 2011). There is a plethora of evidence affirming that genetic vulnerability causes defects in identical chromosomes and further predispose the vulnerability. Every single gene exerts small effects on the chromosomes and causes schizophrenia and the entire set of genes can be passed on to the next generation. The research aims to analyze the genetics of schizophrenia and its etiology in terms of the amount of copy number variants, rare coding inherited, and the de novo variants (Avramopoulos, 2018). For example, the study will look into the type of RNA that binds the fragile X-related protein FMRP in relation to those of the activity-regulated cytoskeletal complex that regulates both learning and memory (Avramopoulos, 2018). To some extent, gene-environment interactions play significant roles in increasing the risk of schizophrenia as evident in adoption studies, which is considered a psychological aspect. Similarly, twin studies reveal the interplay between the environment and hereditary genes that lead to differences in monozygotic and dizygotic twins (Gejman, Sanders & Duan, 2010). Additionally, the biological pathways leading to Schizophrenia relate to simple Mendelian disorders that result in unexpectedly intricate genetic arrangements. Therefore, it is the biological complications that lead to neuronal disconnections and permutations in the physiological functioning of higher brain functions; hence, rendering them incomplete. The arrangement of the family, access to medical care, and the ability to cope effectively can lead to an increased risk of mental health illnesses like schizophrenia. Furthermore, racial disparities contribute to the risk of mental health illnesses. For instance, Blacks and some Latino Americans who have limited access to health care are prone to psychotic disorders, schizophrenia alike. Findings from other studies maintain that a greater percentage of carriers can increase the risk of schizophrenia, particularly for the case of identical twins. Therefore it is crucial to examine the impacts of psychological, environmental, ethnic, and sociological factors on chromosomal aberrations that increase the risk of schizophrenia.
References
Avramopoulos, D. (2018). Recent Advances in the Genetics of Schizophrenia. Mol Neuropsychiatry, 4:35–51. Baltimore: Karger AG, Basel. Retrieved January 17, 2020, from https://www.karger.com/Article/Pdf/488679
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Bassett, A. S. (2011). Chromosomal Aberrations and Schizophrenia: Autosomes. Br J Psychiatry , 161: 323–334. Canadian Institute of Health Research. Retrieved January 16, 2020, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188307/pdf/nihms1832.pdf
Gejman, P. V., Sanders, A. R. & Duan, J. (2010). The Role of Genetics in the Etiology of Schizophrenia. Psychiatr Clin North Am , 33(1): 35–66. NIH. Retrieved January 16, 2020, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826121/pdf/nihms164007.pdf
