Amyotrophic lateral sclerosis is a neuron disease that affects brain cells and the spine causing progressive loss of muscle control. There is no known cure for ALS. It often starts with easily identifiable symptoms such as slurred speech and numbness in the limbs. Progressive bulbar palsy is the deterioration of the brain stem, which is the part involved in activities such as swallowing and speaking. Progressive bulbar palsy is considered a variant of ALS (Yedavalli, 2018). People with PBP later develop ALS. It has no cure. Huntington's disease is a disease that causes degeneration of the brain's nerve cells. It impacts a person's cognitive and movement abilities.
Similarities
The three diseases cause difficulty in swallowing and speaking. This is because they affect parts of the brain that make these functions possible. The disorders also affect individual movement abilities and general limb weakness. The diseases cause an outburst of emotions such as crying and laughing (L, Diagnosis of amyotrophic lateral sclerosis, and other forms of motor neuron disease. , 2015).
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Differences
Huntington's disease is genetically inherited, while ALS is inherited only in 10% of the case. Progressive (Tada, 2012) Bulbar Palsy is not inherited. Huntington's disease causes a myriad of psychiatric problems such a bipolar, depression, mania, and OCD. ALS, on the other hand, causes dementia in some cases. ALS mostly affects people between 40 and 60 years while Huntington's disease and PBP affect even people under the age of 20 even though they are more prevalent from middle age.
These three diseases are interconnected, and the best education plan is to go through an in-depth literature analysis of their relationships and how they are managed. The diseases affect a similar population and have identical management strategies (L & Mculeksy, 2015). These diseases should be studied together. Progressive Bulbar Palsy, in most cases, leads to ALS, and Huntington's disease is genetically inherited. The relationship between PBP and ALS needs to be established clearly, and people who have Huntington's disease should have more choices.
References
L, E. (2015). Diagnosis of amyotrophic lateral sclerosis and other forms of motor neuron disease. . UptoDate .
L, E., & Mculeksy, L. (2015). Features of amyotrophic lateral sclerosis and other forms of motor neuron disease. Shefner JM .
Tada, M. (2012). Coexistence of Huntington’s disease and amyotrophic lateral sclerosis: a clinicopathologic study. NCBI .
Yedavalli, V. S. (2018). Amyotrophic Lateral Sclerosis and its Mimics/Variants: A Comprehensive Review. Journal of Imaging Science .
