Norquist, B. M., Garcia, R. L., Allison, K. H., Jokinen, C. H., Kernochan, L. E., Pizzi, C. C., . . . Swisher, E. M. (2010). The molecular pathogenesis of hereditary ovarian carcinoma. Cancer, 116 (22), 5261-5271. doi:10.1002/cncr.25439
The study investigates the changes in BRCA1/2 tubal epithelium in explaining the pathophysiology of ovarian cancers. The study was conducted on 207 subjects with the aim of characterizing the molecular activities that differentiate the epithelium found in the fallopian tubes of women with BRCA1 or BRCA 2 mutations and those women without. The findings from this randomized control trial suggest that an estimated 10-15% of ovarian cancers are acquired mutations in BRCA1 and BRCA2.
Delegate your assignment to our experts and they will do the rest.
Ovarian cancer is ranked 7 th among the common cancers found in women throughout the world. It is ranked second in causing deaths among women in gynecological malignancies (Russell, 2010). Nevertheless, ovarian carcinomas are identified as the most dangerous in all gynecological malignancies.
The results of the study show that initial tubal proliferation as examined using Ki-67 staining was high in BRCA1 when compared with the control group. Subjects identified with BRCA1 and BRCA 2 had a high p53 foci for every tubal part than the control group (p=0.02). In addition, p27 was reduced in 12 out of the 28 p53 foci subjects who had BRCA1 mutations and none out of the sixteen subjects in the control group.
The data collected from the study contributes to the expansion of the BRCA1/2 model and more molecular information. Previously, other researchers proposed the same model founded on the development of p53 foci to undisguised neoplasia (Norquist et al., 2010). The study proposed that cases of haplinadequacy of BRCA1 cause an expansion of epithelial proliferation of fallopian tubes.
Topic Reflection
Important knowledge on pathogenesis has been gained throughout the course. An important concept learned in the course is application of pathophysiology science in diseases/disorders in the lifespan. However, understanding the pathogenesis of cancers has been a major challenge considering the complicated nature of the disorder. Extensive reading will be ensured in order to improve understanding of the area.
Reference
Norquist, B. M., Garcia, R. L., Allison, K. H., Jokinen, C. H., Kernochan, L. E., Pizzi, C. C., . . . Swisher, E. M. (2010). The molecular pathogenesis of hereditary ovarian carcinoma. Cancer, 116 (22), 5261-5271. doi:10.1002/cncr.25439
Russell, S. E. (2010). The Molecular Pathogenesis of Ovarian Cancer. Ovarian Cancer, 25-36. Doi: 10.1385/1-59259-071-3:25
