Media plays a central role in disseminating medical and technological information to people. The significance of media coverage of medical information related directly to what students learn in medical class. For the past few years, newspapers, magazines, blogs, radios, and television have covered unending information concerning vitamin D. There has been a rising concern indicating an extreme pervasiveness of low intake and low status of vitamin D among people across all classes. The media has channeled its effort in highlighting Vitamin D's biochemistry to the public understand the health risks related to low Vitamin D status. Therefore, this has led to improved dissemination of information concerning the biochemistry of vitamin D to students, the public, and health care professionals. This paper will discuss how the coverage of vitamin D's biochemistry by the media is directly related to the information provided in class.
The article “Vitamin D Biochemistry” by Dr. Liji Thomas provides an in-depth examination of vitamin D’s biochemistry. According to Thomas (2018), vitamin D is sorted into two structures: vitamin D2 and D3. The two types of Vitamin D contrast in the composition of their side chains: ergocalciferol for Vitamin D 2 and cholecalciferol for Vitamin D3. The two classes are equivalent to their natural capacity and reporter in dose. In addition, both Vitamin D2 and Vitamin D3 are consumed by being converted into the 25-hydroxy. They are later transformed into the bioactive Vitamin D form in the kidney (Feldman et al., 2017), giving a structure that is like other steroid hormones delivered in the body. The report delivered by the News Medical Life Sciences on Vitamin D Biochemistry confirmed what we have learned concerning the Vitamin D sources. Vitamin D2 is generally delivered on a commercial scale through yeast illumination but at the same time is found in a couple of plant sources. On the other hand, Vitamin D3 has various sources, for example, ingested in egg yolk, remote ocean greasy fish, or being created by bright radiation following up on the parent compound.
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Vitamin D is ergosterol, which is a derivative of 7-dehydrocholesterol. The conversion of vitamin D is attributed to infrared radiation's action on the parent compound made in the Malpighian skin layer through a moderately minor cholesterol synthesis route. Secosterol compound is formed when infrared radiation between frequencies 290-315 nm brings about the holding in the ninth and the tenth situation of the steroid ring to open. Subsequently, this goes through a further cis-to-trans transformation through the arrangement of a connection betwixt the fifth and sixth carbon particles that results in the vitamin D3 formation. In this process, the presence of ultraviolet radiation has resulted in vitamin D being referred to as the ‘sunshine vitamin. Vitamin D3, therefore, moves to the liver; at the liver, mitochondrial chemical hydroxylase discharges the hydroxyle bunch on th 25 positions (Binkley et al., 2017). For this response to happen, the energy is needed as oxygen and NADPH. Consequently, prompting the creation of 25-hydroxy cholecalciferol, which is the idle stockpiling type of vitamin D3 is stored in the liver.
Where important, 25-hydroxy cholecalciferol is conveyed to the renal where a subsequent reaction takes place at one position; this reaction changes it to the bioactive vitamin D form . The enzyme released in the kidney regulates the production of the bioactive form of Vitamin D that is mostly influenced by various aspects such as feedback from vitamin D, which is in an active form that is currently present in the blood system, calcium, and phosphate level, as well as the release of parathyroid hormone that are the main target of vitamin D action. On the other hand, calcitriol is shipped through the circulation system to the intestinal mucosa (Feldman et al., 2017). At the intestinal mucosa, 1.25-dihydroxy cholecalciferol stimulates phosphate and calcium; the two mineral ions are significant in bone development and other supportive tissues. The ions also important promote bone development and rebuilding by osteoclasts and osteoblasts.
Vitamin D is needed to maintain normal calcium and phosphate; the two ions, calcium and phosphate, are needed for nerve conduction, bone mineralization, general blood circulation in the body cells, and muscle contraction. However, Vitamin D can only achieve this after its transformation to the bioactive form calcitriol or 1.24- 1,25-dihydroxy (Van Schoor & Lips, 2017) . Calcitriol regulates the transcription of several vitamin D-dependent genetic factor coding for bone matrix proteins and calcium-transporting protein. Vitamin D modulates the transcription cycle proteins cells, which declines cell proliferation and increases cell differentiation of specialized body cells such as precursors, osteoclastic, keratinocytes, and enterocytes. Therefore, this property explains vitamin D's action in intestinal calcium transport, bone resorption, and skin (Binkley et al., 2017). Moreover, vitamin D possesses immune-modulatory features which might alter reactions to infections in vivo. The reasons why vitamin D derivatives are utilized successfully in the treatment of skin disorders such as psoriasis underlies the immune-modulatory properties and cell differentiating.
The primary function of vitamin D is controlling the take-in of calcium in the body. It promotes the assimilation of calcium from the gut , enabling the mineralization of osteoid tissue in bones and facilitating muscle functioning. Therefore, prolonged deficiency of vitamin D is detrimental to the skeleton, leading to rickets in kids and osteomalacia in older adults (Van Schoor & Lips 2017). Subsequently, serum 25 (OH)D focuses on these issues range from the untraceable to about 20nmol/l . Vitamin D insufficiency, often referred to as less severe Vitamin D deficiency, may bring about auxiliary hyperparathyroidism, muscle shortcoming, bone misfortune, falls, and fragility fractures in adults. According to medical reports, vitamin D is responsible for maintaining regular teeth and bones, normal development and growth of bones in children, assimilation and utilization of calcium and phosphorus, maintenance of regular muscle function, and normal blood calcium concentrations.
Considering the above info on the biochemistry of vitamin D and its significances, it evident that media coverage is directed related to information disseminated in class in various ways. First, the class lecture is more centralized on the two forms of vitamin D, vitamin D2 & D3, that contrast in the form of the side chains . The conversion of vitamin D is attributed to infrared radiation on the parent compound made in the Malpighian skin layer through a moderately minor cholesterol synthesis route. Lastly, the media coverage on the function of Vitamin D directly correlates with class information, including absorption of calcium from the gut, regular teeth, and bones, normal development and growth of bones to children, assimilation and use of calcium and phosphorus, maintenance of regular muscle function.
References
Binkley, N., Dawson-Hughes, B., Durazo-Arvizu, R., Thamm, M., Tian, L., Merkel, J. M., ... & Sempos, C. T. (2017). Vitamin D measurement standardization: The way out of the chaos. The Journal of Steroid Biochemistry and Molecular Biology , 173 , 117-121.
Feldman, D., Pike, J. W., Bouillon, R., Giovannucci, E., Goltzman, D., & Hewison, M. (Eds.). (2017). Vitamin D: Volume 1: Biochemistry, Physiology, and Diagnostics . Academic Press.
Thomas, L. (2018). Vitamin D Biochemistry. News Medical Life Sciences . https://www.news-medical.net/health/Vitamin-D-Biochemistry.aspx
Van Schoor, N., & Lips, P. (2017). Global overview of vitamin D status. Endocrinology and Metabolism Clinics , 46 (4), 845-870.
