Mechanism proposed for the Influence Dendritic Cells Have On Asthma Exacerbation.
Asthma exacerbation is considered deadly in humans, and as such, dendritic cells initiate a mechanism to deal with the mentioned situation. In the case of asthma, TSLP, IL-33, and IL-25 are produced in the airway epithelial cells that conditions DCs to enhance type 2 immune responses. Conversely, experimental asthma is protected through induction of A20 in epithelial cells and by inhibiting DC activation. DCS are the major source of IFNthat stimulates viruses, and are lodged to the airway respiratory tract viral infections. The infections are the precipitants causing asthma exacerbation.
Cytokines Involved in Asthma, COPD and Respiratory Bacterial Infections
In their context, Dendritic cells (DCs) have a significant role of initiating immune responses in form of cytokines in order to assist the body fight against asthma, COPD and respiratory bacterial infections. They have the ability of determining the type of T-lymphocyte differentiation suitable in the event of the afore-mentioned infections. Some of cytokines include IL-4, IL-12, IL-10, IL-6 and TGF-B. In that sense, DCs have a major role in releasing the required cytokines that produce the required immune response and allergic inflammation associated with asthma.
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Basic Difference between Cell Mediated and Humoral Immunity
Cell mediated immunity protects the body against intracellular pathogens. In contrast, humoral immunity protects the body system against the extracellular micro-organisms. The activation of cell mediated immunity releases cytokines, and whenever the humoral immunity cells are activated, plasma B cells undergo differentiation and antibodies are secreted. The mediated immunity cell use T-cells as the main cells, which are manufactured in the bone marrow. In contrast, the B-cells are the main cells and are manufactured in the bone marrow. The onset of cell mediated immunity cells are delayed, while a rapid onset is evident in the humoral immunity cells.
