Phenylketonuria (PKU) - Symptoms, Causes, and Treatment

Part I

Q1. Difficulties in concentration, remembering and paying attention. 

Q2. Central nervous system/brain 

Q3. Her recessive genes cannot make hydroxylase, responsible for breaking down phenylalanine. 

Q4. Parents. Heterozygous for PKU gene or pq 

Q5. Either pq or p2 

Q6. q2 

Part II- Hardy-Weinberg 

Q1. Unless you know the population size it's difficult. There are additional aspects to consider before you finalize the equation. 

Q2.Yes, they can. Frequency of dominant allele, recessive allele frequency, homozygous dominant frequency, heterozygotes frequency, and homozygous recessive frequency. 

Part III – Carriers 

Q1. Take the square root of q2 

Q2. 

p + q = 1 

p=1-q 

Q3. 

33/300,000=0.011%. So q is 300,000x0.011 

=3300 

Q4. Random allele frequency changes, natural selection, genetic drift, mutation, gene flow, and mating behavior. 

Q5. They were right, that means that their reason was appropriate in this case 

Q6. 

Janes’s chances -2pq 

Janes's husband chances- 2pq 

Chances for a PKU child is 2pq x 2pq x 0.25 = 0.000108 

Q7. 

Amanda chances - 2pq 

Amanda's husband-2pq 

Chances for a PKU child is 2pq x 2pq x 0.25 = 0.000108