The human body carries a lot of microbes that amount up to 2 kg. The bacteria present in the intestines of each. About two-thirds of this microbiome is unique to different individuals. The Micro gut biome has been in recent years being researched on how they influence the health of human beings. Constant growth and evolution are happening on the gut microbiome in the human body right from the young age to the old age. The scientists want to identify how this unique bacterium affects our health. This paper will highlight the health concern surrounding cancer by thoroughly examining both the research as well as claims on the gut microbiome.
The link between cancer and gut bacteria has begun to slowly get established in recent years. According to Honor Whiteman, (2015) there was a research study conducted in the year 2013 by some US researchers working for ‘The Journal of Cancer Research' that claimed the development of the white blood cells cancer known as lymphoma might be as a result of Lactobacillus johnsonii. This particular bacterium was found to be hosted inside the intestines. Another research conducted showed improved survival of mice with intact microbiomes after approved platinum chemotherapy shrank a variety of implanted tumors.
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Icahn School of medicine conducted the third research in the year 2014 in New York. Colorectal cancer development was associated with a specific combination of Gut bacteria (Whiteman, 2015). The mice that had gene mutations known to cause colorectal polyps that would later develop into cancer were taken and administered with some antibiotics. The gut bacteria of the mice were interfered with once they administered the antibiotics. The mice did not develop polyps, according to the researchers. This experiment might indicate that the involvement of gut microbes may cause the development of cancer.
From the final experiment discussed above conducted by the researchers at Icahn School, I can draw a few conclusions in line with the gut microbiome. We have seen that once the antibiotics interfered with the gut bacterium, the mice did not develop the colorectal polyps a condition that usually leads to cancer. This is a clear indication that the gut microbiome, in most cases, is fully involved in the development of cancer in the human body. Nevertheless, the second experiment where the mice with intact gut microbiome survived after shrinking all the tumors is also an interesting subject.
This shows that some microbes appear to protect us from cancerous growths; others seem to take part in promoting the cells proliferation process hence making the whole relationship between cancer and microbiome a complex one. The disorders that generate one cancer may have a contrasting result in another in various cases. The carcinogenesis may get affected through other mechanisms or inflammation since it's pretty obvious that the commensal microbiota is involved. An understanding of the specific species, as well as the type of bugs that are involved in certain changes, is the best move the researchers will make. This will help in trying to alter the balance towards getting the right results.
There is involvement of several therapies since they differ from one type of cancer to the other. As for prostate and breast cancer, hormonal therapy is the common treatment used. This type of therapy is meant to change the behavior of some hormones when the patient takes some medication (Nall, 2018). Alternatively, the medication can interfere with the body's ability to produce some hormones. Also, in other cases, radiation therapy gets used. In this case, the cancerous cells get shrank by the use of high doses of radiation. Also, before commencing a surgery, the doctor might request that the tumor-related symptoms get reduced by using the radiation.
Additionally, monoclonal antibodies and small molecule drugs are some of the examples of targeted therapies. These kinds of therapies prevent the multiplication of cancerous cells by performing various functions within the body (Nall, 2018). These functions also help in boosting the immune system of the individual. To me, these therapies are a good thing. Therapy helps a patient to be able to minimize the various multiplications of cancerous cells as well as reduce the pain endured by the patients.
Several microbiotas influence the susceptibility of cancer, and they get harbored in the human body. These microbiotas can do so due to their influence that is profound on the function of the immune cell as well as their prodigious metabolic capacity. In line with the therapies as well as the treatment of cancer, there is emerging evidence that the microbiota can get manipulated to improve the process (Bhatt et al., 2017). The microbiota can get harnessed to improve cancer care through designing minor iotas that aim microbial enzymes or by incorporating probiotics as adjuvants for checkpoint immunotherapy. The claims are not far from some research that we discussed in this paper where the gut microbiome shrank the tumor during an experiment.
Currently, a lot of individuals are suffering from various types of cancer, with the numbers increasing day by day. The therapies that I have stated in this paper are some of the ways that can be used to regulate the multiplication of the cancerous cells. The therapies act as a remedy for this disease since the cure has not been established yet. I would recommend that anyone who has cancer to try out the various therapies discuss to be able to contain the multiplication of the cancer-related cells.
References
Bhatt, A. P., Redinbo, M. R., & Bultman, S. J. (2017). The role of the microbiome in cancer development and therapy. CA: a cancer journal for clinicians , 67 (4), 326-344.
Nall, Rachel. (2018) What to know about cancer. https://www.medicalnewstoday.com/articles/323648.php
Whiteman Honor, (2015) The gut microbiome: How does it affect our health? https://www.medicalnewstoday.com/articles/290747.php
