Stem cell treatment has come out as a very promising treatment method for numerous body complications due to the stem cells' ability to accelerate tissue regeneration. Various stem cells have been proven to facilitate the regeneration of damaged tissues in the body. Some stem cells that are well known in treating various body complications are hematopoietic stem cells, mesenchymal stem cells, and CD44 stem cells. This breakthrough in stem cell research has made it easy to treat wounds and other illnesses whose healing is dependent on the regeneration of damaged tissues. Besides treating wounds, stem cells also help in the generation of mature blood cells and platelets, which are all crucial in healing processes. Therefore, stem cells are important in the body as they help generate blood cells, heal diabetic ulcer wounds, and treat ovarian cancer.
Stem cells help generate mature blood cells and platelets in the bone marrow, which facilitate healing in the body, especially in wounds. Blood cells are generated in the blood stem cells and are normally formed in the bone marrow via hematopoiesis, which is a highly regulated process. Blood stems cells, also referred to as hematopoietic stem cells, which are immature cells, have the ability to transform into different types of blood cells (Frisch, 2019). The blood stem cells often develop to become mature blood cells. Each blood cell promotes healing in the body. The red blood cells help in the creation of collagen on wounds, which forms the foundation for new tissues, while the platelets help in preventing blood loss in injuries, and the white blood cells help in cleaning the wound and fighting infections, facilitating faster wound healing (Rodrigues et al., 2019). Therefore, the ability of the stem cells to generate all types of blood cells, which are critical in the wound healing process, makes them core in treating ulcer diabetic wounds.
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Stem cells normally promote wound healing from ulcer complications and help in repairing the cells. Although diabetic ulcer wounds are the hardest to treat due to their deep tissue damage, stem cell research has shown that mesenchymal, an adipose-derived stem cell, promotes the healing of such wounds. Adipose-derived stem cells help treat wounds by recruiting and differentiating endothelial cells that are moderated by the VEGF-PLC-ERK pathway (Chen et al., 2020). The adipose-derived cells (mesenchymal) facilitate the migration of cells, epithelialization, and formation of tissues, resulting in an acceleration in the closure of wounds (Hu et al., 2018). According to Hu et al. (2018), mesenchymal stem cells promote a regenerative tissue environment, which makes facilitates faster wound healing in patients with diabetes or ulcers. Therefore, the ability of stem cells to facilitate the restoration of damaged tissues to their pre-injured state in wounds makes them important in treating the cancer of the ovaries.
Stem cells can heal ovarian cancer from the body. Ovarian cancer is one of the most lethal gynecological diseases in the US as it is often diagnosed at an advanced stage and due to the absence of a highly reliable diagnosis at its early stage, chemo-resistance from the disease, and tumor heterogeneity (Al-Aleim et al., 2018). Additionally, cancer stem cells are highly resistant to chemotherapy and are self-regenerating. However, stem cell research has resulted in the development of alternative treatment options for the disease. Through the study of cancer stem cells, it has become easier to understand and identify the ovarian cancer stem cells pathways, which has become essential in developing new treatment options. According to Al-Aleim et al. (2018), CD44, the binding glycoprotein’s surface that is extendable for all tumors, in particular, is important in healing ovarian cancer. Al-Aleim et al. (2018) note that CD44+MYD88 accelerates the wound healing process through the scratch of assays. It also facilitates tumor repair and restoration after surgery or chemotherapy. By undergoing self-renewal and regeneration, these cells facilitate the healing of ovarian cancer as wounds left after chemotherapy or surgery.
Conclusively, stem cells are very important in treating various body complications, such as ovarian cancer, diabetes ulcer wounds, and the generation of blood cells. In the generation of blood cells, the blood stem cells found in the bone marrow undergo the hematopoiesis process to form blood cells and platelets, each of which plays a critical role in promoting wound healing. Besides, stem cells help in treating ovarian cancer, which is facilitated by CD44+MY88, which facilitates wound healing through cell regeneration after surgery or chemotherapy. Finally, stem cells promote the healing of diabetic ulcer wounds. The mesenchymal stem cells facilitate the restoration of damaged tissues to their pre-injured state. Therefore, stem cells have played a critical role in promoting tissue regeneration, which helps treat different complications in the body.
References
Al-Alem, L. F., Pandya, U. M., Baker, A. T., Bellio, C., Zarrella, B. D., Clark, J., DiGloria, C. M., & Rueda, B. R. (2019). Ovarian cancer stem cells: What progress have we made? The International Journal of Biochemistry & Cell Biology , 107 , 92–103. https://doi.org/10.1016/j.biocel.2018.12.010
Chen, L., Zheng, Q., Liu, Y., Li, L., Chen, X., Wang, L., & Wang, L. (2020). Adipose-derived stem cells promote diabetic wound healing via the recruitment and differentiation of endothelial progenitor cells into endothelial cells mediated by the VEGF-PLCγ-ERK pathway. Archives of Biochemistry and Biophysics , 692 , 108531. https://doi.org/10.1016/j.abb.2020.108531
Frisch B. J. (2019). The hematopoietic stem cell niche: What's so special about bone? Bone , 119 , 8–12. https://doi.org/10.1016/j.bone.2018.05.017
Hu, M. S., Borrelli, M. R., Lorenz, H. P., Longaker, M. T., & Wan, D. C. (2018). Mesenchymal Stromal Cells and Cutaneous Wound Healing: A Comprehensive Review of the Background, Role, and Therapeutic Potential. Stem Cells International , 2018 , 6901983. https://doi.org/10.1155/2018/6901983
Rodrigues, M., Kosaric, N., Bonham, C. A., & Gurtner, G. C. (2019). Wound Healing: A Cellular Perspective. Physiological Reviews , 99 (1), 665–706. https://doi.org/10.1152/physrev.00067.2017
